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9817-18 Introduction to Platelet Structure and Function
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About this item

Course includes study material and exam. 

Description: Learn about platelet production, kinetics and regulation, aggregation and understand the effect of drugs on platelets. Platelet factors and the arachidonic acid-prostacyclin pathways are also discussed.

 

Course/Activity Information

Learning Outcomes:

  • Describe the production of platelets in the body including platelet regulation, kinetics, and lifespan.
  • Describe in detail the ultrastructure of a typical platelet.
  • Draw a platelet showing its ultrastructure.
  • Outline the relationships between the different structural zones of the platelet.
  • Describe the current understanding of the regulatory protein thrombopoietin.
  • Briefly describe the formation of a platelet hemostatic plug.
  • Give a detailed review of the platelet interaction with the vessel wall.
  • Describe the process of aggregation and list the agents that initiate it in vitro.
  • List many of the substances available over the counter that contains aspirin.
  • Outline the logic for daily aspirin therapy.
  • Outline some of the agents that inhibit platelet aggregation.
  • Prepare a list of drugs that have an effect on platelet function
  • Outline the specific features of PF3 and PF4.
  • Describe schematically the arachidonic acid - prostacyclin pathways.
  • List the important compounds released from platelets upon activation.
  • Describe the effect of ethanol consumption on platelets.

 

Author: John Chapman, FCSMLS, FIMLS, CLSp(H)

Version Date: March 2018

 

PEP hours: 13.2

CPS credits: 0.8

*Note: PEP hours and/or CPS credits will only be awarded upon successful completion of Final Exam.

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